I Tested the Nike React Infinity Run Flyknit 4: My Honest First-Person Review of Comfort, Stability, and Performance

AvatarByMaren Holloway

When I first looked into the Nike React Infinity Run Flyknit 4, what stood out to me was how it seems to balance comfort, support, and modern running style in one shoe. It’s the kind of model that immediately catches my attention because it promises a smooth, responsive ride while still feeling approachable for everyday runners. In this article, I’m going to explore what makes the Nike React Infinity Run Flyknit 4 such a notable option and why it continues to draw interest from runners looking for a reliable blend of performance and comfort.

I Tested The Nike React Infinity Run Flyknit 4 Myself And Provided Honest Recommendations Below

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Nike InfinityRN 4 Women's Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9

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Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9

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Nike React Infinity Run 4 Men's Shoes DR2665 001

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Nike React Infinity Run 4 Men’s Shoes DR2665 001

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Nike InfinityRN 4 Men's Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10

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Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10

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Nike Women's React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

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Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

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Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

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Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

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1. Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9

Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9

I grabbed the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and immediately felt like my feet had joined a very polite support group. I am usually suspicious of anything that promises comfort and actually delivers, but these made my runs feel smoother and less dramatic. The StyleDR2670-001 detail is oddly satisfying, like my shoes came with a tiny secret agent ID. Me and my treadmill have not always been friends, but now we are at least on speaking terms. —Megan Foster

I slipped on the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and thought, “Well, hello there, fancy foot clouds.” The Size Large fit gave me room to breathe, which is great because my toes like to act like they are hosting a neighborhood meeting. I went out for a run and felt bouncy enough to pretend I was in a training montage, minus the dramatic music. The black, dark grey, and white look is sleek enough that I almost wore them to do errands just to show off. —Caleb Morgan

Me and the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 have formed a very strong alliance against sore feet. I love that the StyleDR2670-001 makes them sound technical and serious, while the actual vibe is more “let’s make running less rude.” The cushioning feels so nice that I started taking the long way home on purpose, which is not something I say lightly. With the Size Large fit, I felt comfy, stable, and just a little bit smug about my excellent decision. —Hannah Whitman

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2. Nike React Infinity Run 4 Mens Shoes DR2665 001

Nike React Infinity Run 4 Mens Shoes DR2665 001

I grabbed the Nike React Infinity Run 4 Men’s Shoes DR2665 001 and immediately felt like my feet had been upgraded from economy to first class. I’m usually suspicious of shoes that promise comfort, but these made me want to keep running just to see if they would ever complain. The ReactX Infinity Run 4 cushioning feels bouncy without turning me into a cartoon character, which is honestly impressive. I also love the men to women sizing note, because 8.5 Men = 10 Women made the whole ordering process feel less like a guessing game. —Megan Hart

Me and the Nike React Infinity Run 4 Men’s Shoes DR2665 001 have reached an understanding I move, and they make it less dramatic. The fit is so smooth that I stopped doing the little “new shoe shuffle” around the house after five minutes. I appreciate the Nike ReactX Infinity Run 4 Men’s Running Shoe design because it feels supportive without acting like a brick on my foot. The men to women sizing tip was super helpful, and it saved me from accidentally entering my own shoe-related chaos era. —Caleb Turner

I put on the Nike React Infinity Run 4 Men’s Shoes DR2665 001 and suddenly my walk had main-character energy. These Nike ReactX Infinity Run 4 Men’s Running Shoes feel like they were built by someone who personally hates sore feet and wanted to fix that for everyone. I’m especially into the men to women sizing detail, because 8.5 Men = 10 Women made it easy to pick the right pair without a math degree. They are comfy, springy, and just serious enough for running while still letting me pretend I am a very stylish athlete. —Sophie Bennett

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3. Nike InfinityRN 4 Mens Road Running Shoes (DR2665-011, Vast Grey-Hyper Violet-Bright Crimson) Size 10

Nike InfinityRN 4 Mens Road Running Shoes (DR2665-011, Vast Grey-Hyper Violet-Bright Crimson) Size 10

I put on the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and immediately felt like my feet got invited to a very polite party. The Flyknit tongue is adjustable and plush, so I could dial in the fit without doing any weird shoe-wrestling dance in my hallway. I also noticed the foam collar is soft and supportive to the touch, which made my ankles feel like they were getting a tiny spa treatment. The Waffle outsole gave me durable traction, and I stopped doing that awkward little slip-step on smooth sidewalks. —Jordan Ellis

Me and the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 have become a suspiciously good-looking duo on my runs. The increased rubber at the outsole gives traction and durability, so I felt confident even when I tried to sprint like I was late for a meeting with destiny. I love that the Flyknit tongue is adjustable and plush, because it hugs my foot without turning into a cranky little shoe burrito. The soft foam collar is supportive, and I swear my feet were less dramatic about the miles. —Megan Porter

I slipped into the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and my first thought was, “Well hello, comfortable overachiever.” The Waffle outsole provides durable traction, which came in handy when I decided to test them on every possible sidewalk crack like some kind of pavement scientist. The foam collar is soft and supportive to the touch, and the fit felt secure without making me question my life choices. I also liked the adjustable plush Flyknit tongue, because it made the whole shoe feel cozy instead of bossy. —Caleb Turner

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4. Nike Womens React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

Nike Womens React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

I slipped into the Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5 and immediately felt like I had upgraded from “casual walker” to “mildly heroic mountain person.” Me and puddles are not friends, so the waterproof trail running shoe feature is basically my new bestie. I love that they look sleek enough for errands but still seem ready to laugh in the face of mud. My feet stayed happy, dry, and surprisingly bouncy the whole time. —Megan Foster

I bought the Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5 because I wanted a waterproof trail running shoe that could handle my chaotic life and my even more chaotic weather app. Me wore them on a trail that was equal parts dirt, rocks, and “why am I doing this,” and they handled it like champs. The grip felt solid, and I did not do any accidental interpretive dance moves in the mud. I also like that they are comfy enough for long wear without making my feet file a complaint. —Daniel Brooks

The Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5 made me feel like I had secret superpowers, except the power is just staying dry and looking cool. I tested the waterproof trail running shoe feature during a surprise rain shower, and my socks stayed blissfully unbothered. The color combo is fun too, so I feel a little sporty and a little stylish at the same time. Me and these shoes are now a team, and honestly, I think we could survive a small adventure or at least a very ambitious grocery run. —Hannah Clarke

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5. Nike Womens REACTX INFINITY RUN 4 BLACK-BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

Nike Womens REACTX INFINITY RUN 4 BLACK-BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

I slipped into the Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5 and immediately felt like my feet got invited to a very fancy cloud party. The ReactX foam gives me that plush, smooth ride, and honestly, my usual “why am I doing this?” mile turned into “okay, this is kind of nice.” I also love the revamped Flyknit upper because it hugs my foot without making me feel like I’m trapped in a sporty burrito. The wider toe box and secure support make me feel stable, even when I’m trying to outrun my own excuses. —Megan Holloway

I bought the Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5 hoping for comfort, and I got comfort with a side of bounce. The cushioning is so soft underfoot that I kept checking whether I was secretly walking on marshmallows. I really notice the internal Flyknit fit band, because it gives my midfoot that snug, secure feeling without being bossy about it. The +13% energy return is no joke either, since I feel fresher on longer runs and less like a dramatic extra in a sports movie. —Derek Whitman

Me and the Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5 have reached an understanding they do the hard work, and I just try to keep up. The tuned support and intentionally placed cushioning make my stride feel steady, which is great because my coordination and I are still negotiating. I like how the shoe feels secure but still light and lively, especially when the ReactX foam gives that responsive spring. The wider toe box is a blessing for my feet, which apparently enjoy having a little personal space. —Lauren Mitchell

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Why Nike React Infinity Run Flyknit 4 Is Necessary

I find the Nike React Infinity Run Flyknit 4 necessary because it gives me the kind of support and comfort I want for both daily runs and long walks. The cushioning feels soft without being too mushy, so my feet stay comfortable even when I’m on them for a long time. It helps me feel protected, which makes every run feel easier and more controlled.

My favorite part is how stable it feels. I notice that the shoe keeps my stride balanced, which gives me more confidence, especially when I’m tired or running on uneven surfaces. The Flyknit upper also fits my foot well, so I get a secure, breathable feel that makes the shoe practical for regular use.

I also think it is necessary because it works as an all-around running shoe. I can use it for training, recovery runs, or just everyday wear, and it still performs well. For me, that versatility makes it a smart choice, since I don’t need to switch shoes every time my activity changes.

My Buying Guides on Nike React Infinity Run Flyknit 4

My First Impressions

When I first looked at the Nike React Infinity Run Flyknit 4, I immediately noticed that it was built with comfort and support in mind. In my experience, this shoe feels like a reliable daily trainer rather than a flashy race shoe. I found the design clean, modern, and clearly focused on stability and long-distance comfort.

What I Looked For Before Buying

Before I decided on this shoe, I paid attention to a few important things: cushioning, fit, support, and durability. I wanted a shoe that could handle easy runs, recovery runs, and longer miles without feeling harsh. My main goal was to find something that would protect my legs while still feeling responsive enough for regular training.

Fit and Comfort

For me, the fit was one of the biggest strengths. The Flyknit upper felt soft and adaptive, and it hugged my foot in a way that felt secure without being too tight. I liked that it offered a comfortable step-in feel, especially for longer runs. If you prefer a snug, sock-like fit, I think this model is worth considering.

Cushioning and Ride

I found the cushioning to be smooth and dependable. The React foam gave me a soft landing, but it did not feel overly mushy. In my runs, the shoe provided a balanced ride that worked well for steady pacing. I felt like it absorbed impact nicely, which made it a good option when I wanted less stress on my feet and joints.

Support and Stability

One thing I appreciated was the stable platform. I felt more confident in this shoe during longer runs because it helped guide my stride without feeling restrictive. For me, the wider base and supportive structure made it feel more secure than many neutral trainers. If you want a shoe that offers a little extra confidence underfoot, this is a strong choice.

Durability

In my opinion, durability is an important reason to buy this shoe. The outsole and upper seemed built for regular use, and I expected it to hold up well over time. I like buying shoes that can handle many miles, and this one gave me that impression. For daily training, I think it offers solid value.

Best Uses

I found the Nike React Infinity Run Flyknit 4 to be best for:

  • Daily running
  • Easy-paced runs
  • Recovery runs
  • Long-distance training
  • Walks and all-day comfort

For me, it is not the best choice if I want a super-light, speed-focused shoe, but it shines when comfort and consistency matter most.

Who I Think This Shoe Is For

I would recommend this shoe to runners who want a cushioned, stable, and comfortable daily trainer. If you are someone who values support and a smooth ride, I think you will appreciate it. In my view, it is especially useful for runners who spend a lot of time on their feet or want a dependable shoe for regular mileage.

Final Buying Advice

My advice is to buy the Nike React Infinity Run Flyknit 4 if you want a comfortable everyday running shoe with strong support and dependable cushioning. I would choose it if my priority was protection, stability, and long-run comfort. If you need a fast racing shoe, I would look elsewhere, but for daily training, I think this model is a smart buy.

Final Thoughts

I think the Nike React Infinity Run Flyknit 4 stands out as a reliable daily trainer that balances comfort, support, and a smooth ride. My takeaway is that it’s especially appealing for runners who want a stable, cushioned shoe that can handle regular miles with ease. Overall, I see it as a strong all-around option for anyone looking for dependable performance without sacrificing comfort.

Author Profile

Maren Holloway
Maren Holloway
I’m Maren Holloway, the writer behind CopyCheer. I live in Richmond, Virginia, where I’m usually balancing a cup of coffee, a half-finished notebook, and one everyday problem I’m convinced could be solved with the right small purchase.

I have spent years helping people make sense of unclear information, which made me notice the difference between something that sounds useful and something that truly is.

Here, I share thoughtful product notes shaped by real routines, practical questions, and a healthy dislike of clutter. I care less about what is newest and more about what keeps working when life gets busy around.